References

Bahr S, Mustafi N, Hättig P Clinical efficacy of a new monofilament fibre-containing wound debridement product. J Wound Care. 2011; 20:(5)242-248 https://doi.org/10.12968/jowc.2011.20.5.242

Bailey E, Kroshinsky D. Cellulitis: diagnosis and management. Dermatol Ther. 2011; 24:(2)229-239 https://doi.org/10.1111/j.1529-8019.2011.01398.x

British National Formulary. Topical corticosteroids. 2022. https://bnf.nice.org.uk/treatment-summaries/topical-corticosteroids/ (accessed 17 September 2022)

Chi YW, Raffetto JD. Venous leg ulceration pathophysiology and evidence based treatment. Vasc Med. 2015; 20:(2)168-181 https://doi.org/10.1177/1358863x14568677

Chapman ALN, Patel S, Horner C Updated good practice recommendations for outpatient parenteral antimicrobial therapy (OPAT) in adults and children in the UK. JAC Antimicrob Resist. 2019; 1:(2) https://doi.org/10.1093/jacamr/dlz026

Diagnostic accuracy in patients admitted to hospitals with cellulitis. 2011. http://dermatology.cdlib.org/1703/1_originals/1_10-00308/article.html

Dalal A, Eskin-Schwartz M, Mimouni D, Ray S, Days W, Hodak E, Leibovici L, Paul M. Interventions for the prevention of recurrent erysipelas and cellulitis. Cochrane Database Syst Rev. 2017; 6:(6) https://doi.org/10.1002%2F14651858.CD009758.pub2

Diaz JH. Skin and soft tissue infections following marine injuries and exposures in travelers. J Travel Med. 2014; 21:(3)207-213 https://doi.org/10.1111/jtm.12115

Dimitrova M, Gilchrist M, Seaton RA. Outpatient parenteral antimicrobial therapy (OPAT) versus inpatient care in the UK: a health economic assessment for six key diagnoses. BMJ Open. 2021; 11:(9) https://doi.org/10.1136/bmjopen-2021-049733

Edwards G, Freeman K, Llewelyn MJ, Hayward G. What diagnostic strategies can help differentiate cellulitis from other causes of red legs in primary care?. BMJ. 2020; 368 https://doi.org/10.1136/bmj.m54

Eklöf B, Rutherford RB, Bergan JJ Revision of the CEAP classification for chronic venous disorders: consensus statement. J Vasc Surg. 2004; 40:(6)1248-1252 https://doi.org/10.1016/j.jvs.2004.09.027

Eron LJ, Lipsky BA, Low DE, Nathwani D, Tice AD, Volturo GA. Expert panel on managing skin and soft tissue infections. Managing skin and soft tissue infections: expert panel recommendations on key decision points. J Antimicrob Chemother. 2003; 52:i3-17 https://doi.org/10.1093/jac/dkg466

Consensus guidance for the use of debridement techniques in the UK. 2011. https://lohmann-rauscher.co.uk/downloads/clinical-evidence/Consensus_guidance_f.pdf

Grudzinska E, Czuba ZP. Immunological aspects of chronic venous disease pathogenesis. Cent Eur J Immunol. 2014; 39:(4)525-431 https://doi.org/10.5114/ceji.2014.47740

Hirschmann JV, Raugi GJ. Lower limb cellulitis and its mimics: part I. Lower limb cellulitis. J Am Acad Dermatol. 2012; 67:(2)163.e1-12 https://doi.org/10.1016/j.jaad.2012.03.024

Hirschmann JV, Raugi GJ. Lower limb cellulitis and its mimics: part II. Conditions that simulate lower limb cellulitis. J Am Acad Dermatol. 2012; 67:(2)177.e1-9 https://doi.org/10.1016/j.jaad.2012.03.023

Jain SR, Hosseini-Moghaddam SM, Dwek P Infectious diseases specialist management improves outcomes for outpatients diagnosed with cellulitis in the emergency department: a double cohort study. Diagn Microbiol Infect Dis. 2017; 87:(4)371-375 https://doi.org/10.1016/j.diagmicrobio.2016.12.015

Kilburn SA, Featherstone P, Higgins B, Brindle R. Interventions for cellulitis and erysipelas. Cochrane Database Syst Rev. 2010; 2010:(6) https://doi.org/10.1002/14651858.cd004299.pub2

Levell NJ, Wingfield CG, Garioch JJ. Severe lower limb cellulitis is best diagnosed by dermatologists and managed with shared care between primary and secondary care. Br J Dermatol. 2011; 164:(6)1326-1328 https://doi.org/10.1111/j.1365-2133.2011.10275.x

Marwick C, Broomhall J, McCowan C, Phillips G, Gonzalez-McQuire S, Akhras K, Merchant S, Nathwani D, Davey P. Severity assessment of skin and soft tissue infections: cohort study of management and outcomes for hospitalized patients. J Antimicrob Chemother. 2011; 66:(2)387-397 https://doi.org/10.1093/jac/dkq362

Adult anthropometric measures overweight and obesity. 2015. http://healthsurvey.hscic.gov.uk/media/1021/chpt-10_adult-measures.pdf (accessed 13 September 2022)

NHS England. NHS Right Care scenario: The variation between sub-optimal and optimal pathways. 2017. https://www.england.nhs.uk/rightcare/wp-content/uploads/sites/40/2017/01/nhs-rightcare-bettys-story-narrative-full.pdf (accessed 13 September 2022)

Nazarko L. Cellulitis: correct diagnosis and treatment of red legs. Dermatology in practice. 2016a; 22:2:50-54

Diagnosing and treating venous eczema. 2016b. https://www.nursingtimes.net/clinical-archive/dermatology/diagnosing-and-treating-venous-eczema-30-11-2016/ (accessed 13 September 2022)

Nazarko L. Solve the case, unilateral leg swelling. Journal of Prescribing Practice. 2019; 1:5:232-238 https://doi.org/10.12968/jprp.2019.1.5.232

Cellulitis. 2022. https://www.bjninform.com/clinical-a-z/cellulitis/ (accessed 13 September 2022)

National Institute for Health and Care Excellence Clinical Knowledge Summaries. Cellulitis acute. 2021. https://cks.nice.org.uk/topics/cellulitis-acute/ (accessed 13 September 2022)

National Institute for Health and Care Excellence Clinical Knowledge Summaries. Venous eczema and lipodermatosclerosis. 2022. https://cks.nice.org.uk/topics/venous-eczema-lipodermatosclerosis/ (accessed 13 September 2022)

O'Brien G, White P. The Red Legs RATED tool to improve diagnosis of lower limb cellulitis in the emergency department. Br J Nurs. 2021; 30:(12)S22-S29 https://doi.org/10.12968/bjon.2021.30.12.s22

Ten top tips for improving the diagnosis of cellulitis in the lower limb. 2015. https://www.woundsinternational.com/uploads/resources/content_11696.pdf

Lipodermatosclerosis. 2018. https://dermnetnz.org/topics/lipodermatosclerosis (accessed 13 September 2022)

Patel M, Lee SI, Thomas KS, Kai J. The red leg dilemma: a scoping review of the challenges of diagnosing lower-limb cellulitis. Br J Dermatol. 2019a; (5)993-1000 https://doi.org/10.1111/bjd.17415

Patel M, Lee SI, Akyea RK A systematic review showing the lack of diagnostic criteria and tools developed for lower-limb cellulitis. Br J Dermatol. 2019b; 181:(6)1156-1165 https://doi.org/10.1111/bjd.17857

Phoenix G, Das S, Joshi M Diagnosis and management of cellulitis.London2012 https://doi.org/10.1136/bmj.e4955

Santer M, Lalonde A, Francis NA Clinical Intelligence. Management of cellulitis: current practice and research questions. British Journal of General Practice. 2018; 68:595-596 https://doi.org/10.3399/bjgp18X700181

Stevens DL, Bryant AE. Impetigo, erysipelas and cellulitis. In: Ferretti JJ, Stevens DL, Fischetti VA (editors). Oklahoma City (OK): University of Oklahoma Health Sciences Center; 2016

Stevens DL, Bisno AL, Chambers HF Infectious Diseases Society of America. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014; 59:(2)e10-52 https://doi.org/10.1093/cid/ciu444

Sullivan T, de Barra E. Diagnosis and management of cellulitis. Clin Med (Northfield Ill). 2018; 18:(2)160-163 https://doi.org/10.7861/clinmedicine.18-2-160

Tidman MJ. Re: Diagnosis and management of cellulitis. Bilateral cellulitis of the legs: does it exist?. BMJ Rapid Response. 2012; 18:(2)160-163 https://doi.org/10.1136/bmj.e4955

Weng QY, Raff AB, Cohen JM Costs and consequences associated with misdiagnosed lower extremity cellulitis. JAMA Dermatol. 2017; 153:(2)141-146 https://doi.org/10.1001/jamadermatol.2016.3816

Wright T, Hope V, Ciccarone D, Lewer D, Scott J, Harris M. Prevalence and severity of abscesses and cellulitis, and their associations with other health outcomes, in a community-based study of people who inject drugs in London, UK. PLoS One. 2020; 15:(7) https://doi.org/10.1371/journal.pone.0235350

Yarbrough PM, Kukhareva PV, Spivak ES, Hopkins C, Kawamoto K. Evidence-based care pathway for cellulitis improves process, clinical, and cost outcomes. J Hosp Med. 2015; 10:(12)780-786 https://doi.org/10.1002/jhm.2433

Clinical and population studies: the effect of aging on venous valves. 2010. http://atvb.ahajournals.org/content/30/10/2075.full

Red legs: how to differentiate between cellulitis, venous eczema and lipodermatosclerosis

02 August 2023
Volume 2023 · Issue 2

Abstract

Nurses often encounter people with red legs. There are a number of reasons why an individual may develop red legs. The most common causes of red legs are cellulitis, venous eczema and lipodermatosclerosis. All have different causes and require different treatments. This article aims to enable readers to differentiate between these conditions which can appear similar, and to offer effective evidence-based care.

Cellulitis is an ambulatory care sensitive condition (ACSC). Its effective management and treatment should prevent admission to hospital; cellulitis is usually diagnosed in primary care and treated at home (NHS England, 2017). Each year, 100 000 people in England are admitted to hospital with cellulitis of the lower leg (Santer et al, 2018).

Misdiagnosis of lower leg cellulitis is common. Around 33% of people diagnosed with cellulitis usually have other conditions and around 90% of people who are misdiagnosed are inappropriately treated with antibiotics (Levell, 2011; Weng et al, 2017; Patel et al, 2019a; O'Brien and White, 2021).

It is vital to accurately diagnose this condition, as an incorrect diagnosis can expose the person to hazards of antibiotic therapy, increase antibiotic resistance and cause delays in providing appropriate effective treatment (Hirschmann and Raugi, 2012a; 2012b). Fig 1 illustrates the consequences of incorrect diagnosis.

Register now to continue reading

Thank you for visiting Wound Care Professional and reading some of our peer-reviewed resources for wound care professionals. To read more, please register today. You’ll enjoy the following great benefits:

What's included

  • Access to clinical or professional articles

  • New content and clinical updates each month